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KMID : 0352720050290010019
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Journal of Ginseng Research
2005 Volume.29 No. 1 p.19 ~ p.26
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Ginseng and ion channels : Are ginsenosides, active component of Panax ginseng, differential modulator of ion channels?
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Jeong Sang-Min
Nah Seung-Yeol
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Abstract
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The last two decades have shown a marked expansion in publications of diverse effects of Panax ginseng. Ginsenosides, as active ingredients of Panax ginseng, are saponins found in only ginseng. Recently, a line of evidences shows that ginsenosides regulate various types of ion channel activity such as Ca²^+, K^+, Na^+, Cl^-, or ligand gated ion channels (i.e. 5-HT₃, nicotinic acetylcholine, or NMDA receptor) in neuronal, non-neuronal cells, and heterologously expressed cells. Ginsenosides inhibit voltage-dependent Ca²^+, K^+, and Na^+ channels, whereas ginsenosides activate Ca²^+-activated Cl^- and Ca²^+-activated K^+ channels. Ginsenosides also inhibit excitatory ligand-gated ion channels such as 5-HT₃. nicotinic acetylcholine, and NMDA receptors. This review will introduce recent findings on the ginsenoside-induced differential regulations of ion channel activities and will further expand the possibilities how these ginsenoside-induced ion channel regulations are coupled to biological effects of Panax ginseng.
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KEYWORD
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